Abstract
Fungal infections have become a subject of great concern and the incidence of fungal
infections is increasing, presenting an enormous challenge to healthcare professionals.
Since most of the fungal infections are occurring over the skin, the treatment option
of these infections always involves topical application. However, in topical delivery
drug reaches into systemic circulation through different barriers of skin. Nevertheless,
due to the low permeability, skin restricts the movement of many drugs. Hence, a delivery
system is required, which deliver the medicament into the skin layers or through the
skin and into the systemic circulation. Ethosomes or Soft malleable vesicles are the
novel lipid vesicular carrier that offer improved skin permeability and efficient
delivery due to their structure and composition. They contain high concentration of
ethanol, which increases the fluidity of the skin. Therefore, in the present paper,
we have explored the utility of ethosomal systems in the topical treatment of fungal
infections. Structure, compositions types, mechanism and techniques of preparation
of ethosome also discussed in the paper.
Key words
Ethosome - fungal infection - topical drug delivery - penetration mechanism - methods
of preparation - application in fungal therapeutics.
